Mist Unit

The Mist Unit is the second and third boss faced in Metal Gear Solid V: The Phantom Pain.

Description
The first encounter with the Mist Unit, a mist-coated Afghanistan plain in Episode 1: Phantom Limbs, is mostly a stealth section, where the player is encouraged to slowly and meticulously sneak past the four Skulls with empty magazines and Miller on your back. The easiest but riskiest option is to completely go loud, put Miller on D-Horse, and ride D-Horse out of the cloud of mist where the unit will quickly pursue with superhuman speed, occasionally stopping to shoot at the player with their assault rifles. While the hits will likely land, they do little damage and the best option is just make a mindless mad dash to the LZ as quickly as possible. For those going for an S-rank, the best tactic is to slowly knock each Skull out with several well placed sleep gas mines.

The second encounter, during the climax of Episode 6: Where Do The Bees Sleep?, has the player cornered at Smaesi Fort, horded with zombies and the automatically alerted Skulls. The Skulls are equipped with assault rifles, machetes they occasionally leap at the player with (countered by a brutal quick-time event), and take cover behind boulders they spawn. The player is equipped with an assault rifle and rocket launcher of their own, one that will easily kill the Skulls in only a few well placed hits. It's, again, possible to simply mount D-Horse and ride out of the mist cloud as quickly as possible.